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  • With the FDA 510(k) clearance, Cryoguard Thermal Exposure Indicators are temperature monitoring devices that help ensure compliance with FDA and CDC guidelines for storing, shipping, and handling vaccines and other heat sensitive medications.
  • Cryoguard™ Thermal Exposure Indicators provide a real time monitoring system capable of alerting staff when the temperature of stored materials has strayed outside acceptable limits as required by the Standards for Tissue Banking of The American Association of Tissue Banks (AATB).
  • The Guidelines of The College of American Pathologists (CAP) states that shipments from a distant referral site to a pathology lab should be shipped under conditions to avoid overheating. Cryoguard Thermal Exposure Indicators verify compliance with that guideline.


At its signal temperature, a Cryoguard indicator irreversibly changes color from green to red within one to two hours. At 10°C to 15°C above its signal temperature the indicator changes color within minutes. At 25°C below its signal temperature the indicator remains green. Cryoguard indicators are available with “signal” temperatures preset at:

     Click Here for Key Information for all Indicators


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What type of materials do Cryoguard indicators monitor?

Customers use Cryoguard Thermal Exposure Indicators to monitor:

  • Stem cells. Cord blood, bone marrow stem cells, peripheral blood stem cells & more
  • Reproductive Samples. Sperm, embryos, vitrified oocytes “eggs,” testicular tissue & more
  • Adhesives. Premixed epoxy resins and polysulfide sealants for aerospace applications & more
  • Vaccines
  • Pharmaceuticals
  • Bone grafts
  • Tissue Samples
  • Organs
  • Blood Products
  • Chemicals
  • Refrigerated or Frozen Products
  • Other Cryopreserved Materials 

Cryoguard Indicators are used to continuously monitor material on/in:

  • Freezer canes
  • Freezer Boxes
  • Dry shippers
  • Liquid nitrogen cooled freezers and dewars
  • Dry ice cooled shipments

Why choose Cryoguard indicators?

Cryoguard Thermal Exposure Indicators are:

Unique. No other temperature sensor provides an at-a-glance warning of thermal exposure from -5°C down to -150°C.

Simple. A green indicator tells you that the monitored material did not suffer potentially damaging thermal exposure.

Economical. Eliminate downloading and returning data loggers, and interpreting data logger print outs.

Versatile. Cryoguard indicators fit in partitioned freezer boxes, attach to most cryovials or snap onto standard cryovial freezer canes.