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At its signal temperature, a Cryoguard indicator irreversibly changes color from green to red within one to two hours. At 10°C to 15°C above its signal temperature the indicator changes color within minutes. At 25°C below its signal temperature the indicator remains green. Cryoguard indicators are available with “signal” temperatures preset at:



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Cryoguard™ LLC’s Thermal Exposure Indicators have been monitoring heat sensitive materials in real time for over 30 years. The indicators were originally developed to assure the quality of frozen blood products being administered on the battlefield. The indicators are now used to signal thermal exposure of frozen specimens such as eggs, sperm, and stem cells. Cryoguard Thermal Exposure Indicators are used for cold chain management by tissue banks, and manufacturers of heat sensitive biologics, premixed adhesives, and heat sensitive electronic components. The indicators verify that the efficacy of sperm, eggs, bone grafts, vaccines, cord blood, blood plasma, stem cells, clinical specimens and premixed epoxy adhesives was not thermally compromised during shipping, storage and handling by technicians and customs inspectors.


With a Cryoguard indicator monitoring your goods, you can tell in an instant (when the indicator is green) that the efficacy of your goods was not compromised by thermal exposure.


Using the indicators eliminates costly and frustrating procedure failures caused by the use of thermally compromised products. 


Use of Cryoguard Thermal Exposure Indicators might have reduced the heart breaking loss of frozen eggs caused by depletion of liquid nitrogen coolant at the Ahuja Medical Center Fertility Center in Cleveland and at the San Francisco Fertility Center - had these centers been using Cryoguard™ Thermal Exposure Indicators in freezer boxes to identify and salvage specimens that escaped potentially damaging thermal exposure.


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What type of materials do Cryoguard indicators monitor?

Customers use Cryoguard Thermal Exposure Indicators to monitor:

  • Stem cells. Cord blood, bone marrow stem cells, peripheral blood stem cells & more
  • Reproductive Samples. Sperm, embryos, vitrified oocytes “eggs,” testicular tissue & more
  • Adhesives. Premixed epoxy resins and polysulfide sealants for aerospace applications & more
  • Vaccines
  • Pharmaceuticals
  • Bone grafts
  • Tissue Samples
  • Organs
  • Blood Products
  • Chemicals
  • Refrigerated or Frozen Products
  • Other Cryopreserved Materials


Cryoguard Indicators are used to continuously monitor material on/in:

  • Freezer canes
  • Freezer Boxes
  • Dry shippers
  • Liquid nitrogen cooled freezers and dewars
  • Dry ice cooled shipments


Why choose Cryoguard indicators?

Cryoguard Thermal Exposure Indicators are:

Unique. No other temperature sensor provides an at-a-glance warning of thermal exposure from -5°C down to -150°C.

Simple. A green indicator tells you that the monitored material did not suffer potentially damaging thermal exposure.

Economical. Eliminate downloading and returning data loggers, and interpreting data logger print outs.

Versatile. Cryoguard indicators fit in partitioned freezer boxes, attach to most cryovials or snap onto standard cryovial freezer canes.